Endocrine Abstracts

Neonatal immune hyperthyroidism is a rare but potentially fatal condition. It occurs in 1–5% of infants born to women with Graves’ disease (GD). We present a case of neonatal thyrotoxicosis due to maternal hypothyroidism secondary to radioactive iodine treatment for Graves’ disease. A new-born female at 13-days of age was readmitted due to maternal concerns. She noted the baby to be jittery, unsettled, tachycardic and tachypnoeic. The infant was born via a spont...

Thyrotoxic storm is one of the rare but serious, and sometimes life threatening endocrine emergencies, the mortality rate ranges from 20 to 30%.We report the case of a 44-year-old female who had an emergency hospital admission with diarrhoea, vomiting and palpitations in September, 2011. She was diagnosed with Graves thyrotoxicosis in 2004 and was commenced on carbimazole. She was non compliant with the treatment and did not attend her hospital appointme...

Hyponatremia complicates 1% of hospital admissions and can be associated with serious CNS effects. We report a case of an 84-year-old woman with longstanding hyponatremia resulting in several hospital admissions because of acute confusion due to severe hypoatremia. This case emphasizes the need to consider selective vasopressin V2-receptor antagonist (Tolvaptan) as a potential therapy for hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone (SIADH)....

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

Introduction and aim: Primary hyperparathyroidism is the commonest cause of hypercalcaemia in out patient population. Primary hyperparathyroidism has become relatively common over the recent years as calcium levels are routinely evaluated since the introduction of multichannel analysers worldwide. Our aim was to audit the use and role of preoperative imaging (Ultrasound and Sestamibi scan) in localising parathyroid adenoma.Methods: We reviewed case notes...

Background: The aim of radioiodine treatment is to ameliorate hyperthyroidism, with minimal risk of hypothyroidism. The Royal College of Physicians recommends the administration of 400–550 Mbq for Grave’s disease and 550–600 Mbq for toxic multinodular goitre.Aim: Our audit aimed to analyze the results of our current practice of radioiodine treatment, and also to compare it with the published results of success rate and hypothyroidism.<...

70-year-old male patient was referred by GP on account of low blood pressure and falling platelet levels. He reported persistent shortness of breath, lethargy and reduced exercise tolerance alongwith 2 stones weight loss with poor appetite in the last 4 months. He has a background history of corneal transplant and was on immunosuppressant therapy including mycophenolate mofetil which was tapered and then stopped few weeks ago when his GP first noticed the low platelet count. H...

A 45 yr lady;presented with lethargy and tiredness, amenorrhea with 2 stone weight loss 3 months after delivery of her baby. Her thyroid functions were done showing low free T4 (0.28 mu/l) as well as low TSH (07 pmol/l). (Thought to be cooling off period of post-partum thyroiditis). She was started on Thyroid hormone replacement (levothyroxine 150 mg once a day) Reviewed again after a month in endocrine clinic, she still feeling tired, lethargic and unwell still not having per...

Case report: Potocki-Lupski Syndrome (PTLS) with obesityEiman Naghmuish1, Marisa Clemente1, Kamal Weerasinghe11Department of Paediatrics, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, The UK.Introduction: Potocki-Lupski syndrome (PTLS) is a rare genetic disorder affecting 1:20.000 people worldwide, it is caused b...

Introduction: Kallmann syndrome (KS) is a developmental disorder characterised by hypogonadotropic hypogonadism and anosmia. 30% of cases are related with genetic causes, with FGFR1 mutations being identified in 10%. There are more than 140 FGFR1 gene mutations identified. We present a female patient with KS due to a FGFR1 mutation, where the presenting features included primary amenorrhoea and anosmia.Case description: ...